ABSTRACT
Objective: To assess the variation of laboratory parameters in COVID-19 positive patients with different genders and age groups and to clarify the consequences of COVID-19 infection on different patients. Study Design: Prospective study. Setting: IHITC (Isolation Hospital & Infectious Treatment Center), Islamabad. Period: 20th May, 2021 to 25th July, 2021. Material & Methods: Study was conducted With 222 participants among them 119 were COVID positive serve as Case and 103 were COVID negative considered as control. Blood samples were drawn from all participants of study to measure biochemical and hematological laboratory parameters with demographic characteristics. Mean ± standard deviation (SD) of different lab parameters analyzed by using IBM SPSS Statistics 20. Results: Total 222 participants were analyzed having 115 (50.7%) male and 107 (49.3%) female having mean age 60±13.8. No significant variation has been seen in ALP, total bilirubin, creatinine and uric acid having mean values with in normal range. In 119 positive patients, ALT (p=0.001) (t=2.031), urea (p=0.001) (t=7.590), Ferritin (p=0.001) (t=7.13), CRP (p=0.001) (t=9.90) and D-dimer (p=0.001) (t=5.962) were elevated and good predictor of poor prognosis of disease. Pathological impacts of COVID-19 were also represented by hematological parameters including WBC count (p=0.001) (t=7.126), Neutrophil to Lymphocyte Ratio (p=0.001) (t=9.042) and Lymphocyte count (p=0.001) (t=-12.707). Conclusion: According to this research, males and old age population is more susceptible to SARS-2. Our study suggests that laboratory biomarkers including ALT, Urea, Ferritin, CRP, D-dimer and WBC count are significantly associated with poor prognosis in Covid-19 patients. [ FROM AUTHOR]